神経成長因子とグリア細胞由来神経栄養因子の協働作用，脳由来神経栄養因子（BDNF）と痛み

In this review we introduce that mixture of low dose NGF and GDNF, which by themselves do not induce mechanical hypersensitivity the muscle, induces statistically significant decrease muscular withdrawal threshold (muscular mechani­cal nociceptive hypersensitivity). The also increases pERK immunoreactivity in DRG neurons responding to stimulation, suggesting collaborative interaction GDNF occurs at level primary afferents. For basis interaction, colocalization their receptors TrkA GFRα1 lumbar dorsal root ganglia is introduced. addition, production receptor for brain derived neurotrophic factor (BDNF) are introduced, then its role pain pathological conditions such as inflammation nerve injury, a possible exercise induced analgesia Finally spinal mechanism BDNF introduced with special emphasis on K+–Cl– cotransporter KCC2.